Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 4.529


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA7chr7_-_271626880.694.3e-03Click!
HOXA6chr7_-_271538920.667.8e-03Click!
HOXB7chr17_-_44042924-0.391.5e-01Click!
HOXB6chr17_-_44037332-0.087.6e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_30544193 12.167 NM_001198941
NM_032978
 DTNA

dystrobrevin, alpha

chr13_-_101852028 11.989 NM_175929
 FGF14
fibroblast growth factor 14
chr9_-_8723893 11.240 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
 PTPRD




protein tyrosine phosphatase, receptor type, D




chr3_-_49372584 11.178 RHOA
ras homolog gene family, member A
chr10_+_69539255 11.149 NM_032578
 MYPN
myopalladin
chr18_-_44723116 10.211 NM_001190823
 SMAD7
SMAD family member 7
chr1_-_27604656 9.401 WASF2
WAS protein family, member 2
chr20_-_1298493 9.372 FKBP1A
FK506 binding protein 1A, 12kDa
chr14_+_51025604 9.285 NM_001042481
 FRMD6
FERM domain containing 6
chr12_+_79362256 9.219 NM_001145026
 PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr16_+_7322751 9.044 NM_145891
NM_145892
NM_145893
 RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr6_+_12825818 8.649 NM_030948
 PHACTR1
phosphatase and actin regulator 1
chr9_+_102380156 8.412 NM_001018116
 MURC
muscle-related coiled-coil protein
chr5_+_59819761 8.247 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr8_-_72431274 8.246 NM_172058
NM_172059
NM_172060
 EYA1


eyes absent homolog 1 (Drosophila)


chr5_-_59819642 8.132 NM_001165899
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_168898898 7.969 PRRX1
paired related homeobox 1
chr8_-_122722674 7.899 NM_005328
 HAS2
hyaluronan synthase 2
chr7_+_113842284 7.886 NM_001172766
NM_014491
NM_148898
NM_148900
 FOXP2



forkhead box P2



chr10_-_92671005 7.806 NM_014391
 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 165 entries
enrichment   p-value GO term description
3.87 1.58e-03 GO:0048665 neuron fate specification
3.11 1.96e-02 GO:0009954 proximal/distal pattern formation
2.95 1.40e-02 GO:0045666 positive regulation of neuron differentiation
2.86 7.15e-04 GO:0048663 neuron fate commitment
2.71 3.93e-05 GO:0007519 skeletal muscle tissue development
2.70 4.49e-02 GO:0001708 cell fate specification
2.66 1.20e-06 GO:0048706 embryonic skeletal system development
2.63 6.46e-05 GO:0060538 skeletal muscle organ development
2.54 2.01e-03 GO:0048704 embryonic skeletal system morphogenesis
2.35 5.99e-03 GO:0009953 dorsal/ventral pattern formation
2.35 2.90e-02 GO:0048634 regulation of muscle organ development
2.34 4.74e-02 GO:0016202 regulation of striated muscle tissue development
2.26 2.28e-07 GO:0045165 cell fate commitment
2.26 3.34e-02 GO:0051147 regulation of muscle cell differentiation
2.25 1.74e-06 GO:0007156 homophilic cell adhesion
2.23 2.12e-05 GO:0014706 striated muscle tissue development
2.20 8.90e-06 GO:0060537 muscle tissue development
2.17 1.13e-08 GO:0007517 muscle organ development
2.15 7.96e-04 GO:0048736 appendage development
2.15 7.96e-04 GO:0060173 limb development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
2.92 7.23e-04 GO:0005581 collagen
2.26 1.47e-06 GO:0030016 myofibril
2.23 5.40e-06 GO:0044449 contractile fiber part
2.20 1.06e-04 GO:0030017 sarcomere
2.18 5.06e-06 GO:0043292 contractile fiber
2.14 5.20e-05 GO:0044420 extracellular matrix part
1.86 6.57e-09 GO:0005578 proteinaceous extracellular matrix
1.79 4.95e-09 GO:0031012 extracellular matrix
1.67 3.77e-02 GO:0005882 intermediate filament
1.56 1.52e-04 GO:0045202 synapse
1.56 4.11e-02 GO:0016323 basolateral plasma membrane
1.51 3.12e-02 GO:0015629 actin cytoskeleton
1.50 8.64e-06 GO:0030054 cell junction
1.42 2.94e-07 GO:0044421 extracellular region part
1.33 5.81e-03 GO:0005615 extracellular space
1.25 1.26e-05 GO:0005576 extracellular region
1.23 8.44e-03 GO:0005856 cytoskeleton
1.21 1.36e-03 GO:0044459 plasma membrane part
1.16 2.06e-05 GO:0005886 plasma membrane
1.16 5.94e-05 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.75 1.54e-15 GO:0043565 sequence-specific DNA binding
1.72 3.11e-02 GO:0008083 growth factor activity
1.71 7.34e-03 GO:0003682 chromatin binding
1.66 5.76e-05 GO:0003779 actin binding
1.60 2.61e-09 GO:0005509 calcium ion binding
1.59 2.37e-14 GO:0001071 nucleic acid binding transcription factor activity
1.59 2.37e-14 GO:0003700 sequence-specific DNA binding transcription factor activity
1.59 1.22e-03 GO:0016563 transcription activator activity
1.58 2.92e-14 GO:0030528 transcription regulator activity
1.56 6.18e-03 GO:0016564 transcription repressor activity
1.45 1.07e-03 GO:0008092 cytoskeletal protein binding
1.35 4.82e-02 GO:0005198 structural molecule activity
1.10 1.81e-04 GO:0005515 protein binding